The molecular signature of heat stress in sweat reveals non-invasive biomarker candidates for health monitoring
A new study by Noé Brasier, MD and colleagues reveals how sweat can provide valuable insights about heat stress and overall health.
Published in Communications Biology (Nature Portfolio), researchers used mass spectrometry to explore the molecular signature of heat stress in sweat.
The team identified a range of promising biomarker candidates — including amino acids and microbiome-related metabolites — that may support non-invasive health monitoring.
Interestingly, several of these molecules have also been observed in heat-stressed animals and plants, hinting at shared biological response patterns across different species.
The research was funded by a MedLab Fellowship to Noé Brasier, MD, and embedded into an Innosuisse-funded project funded to Prof. Dr. Jörg Goldhahn, MD.
Based on an earlier work on using wearable sweat analysis to estimate biological age, the researchers are continuing their exploration on how molecular signatures in sweat could reflect long-term health and aging processes. external page Read the related publication here
You can view the publication at the following link (open-access):
external page Paper Communications Biology (2025)
Author: Noé Brasier / Co-authors: Carmela Niederberger, Martina Zanella, Alaa Othman, Ralph Schlapbach, Laura Kunz, Antje Dittmann, Kelly Reever, Michael Prummer, Jörg Goldhahn